Dr Hao-Wen Sim

A/Prof Hao-Wen Sim

(MBBS Hons, BMedSci, MBiostat, FRACP, GStat)


Medical Oncologist, The Kinghorn Cancer Centre and Chris O'Brien Lifehouse
Clinical Lead and Group Coordinator, Cooperative Trials Group for Neuro-Oncology (COGNO)
Conjoint Associate Professor, University of New South Wales
Senior Research Fellow, University of Sydney

A/Prof Hao-Wen Sim contributes his expertise and leadership in neuro-oncology, trial methodology and biostatistics. He received his medical degree with Honours from The University of Melbourne, being awarded the James Stewart Bequest for Surgery and inducted to the Margaret Whyte Honour Board.

He completed his Master of Biostatistics from The University of Sydney, being awarded the Biostatistics Collaboration of Australia Star Graduate Award, Judy Simpson Biostatistics Scholarship, Les Irwig General Epidemiology Award and Australasian Epidemiological Association Top Student Prize. He also completed neuro-oncology fellowship at the Princess Margaret Cancer Centre in Toronto, Canada. He is a Fellow of The Royal Australasian College of Physicians and a graduate biostatistician of the Statistical Society of Australia. 

A/Prof Sim currently works as lead clinician treating brain cancer patients at The Kinghorn Cancer Centre and Chris O’Brien Lifehouse in Sydney. He is the Clinical Lead and Group Coordinator of the Cooperative Trials Group for Neuro-Oncology (COGNO) and Chair of the COGNO International Clinical Research Subcommittee. 

 A/Prof Sim’s research focus is the design and operationalisation of investigator-initiated brain cancer trials. As a productive mid-career clinical researcher, he has secured over $11.6 million in peer-reviewed funding, multiple awards (including ASCO Merit Award, NOYCIA Award, CAHON Young Investigator Award), and authored 44 peer-reviewed manuscripts (including Journal of Clinical Oncology, Neuro-Oncology, Clinical Cancer Research) and a book chapter. 

Current Projects & Areas of Interest:

  • Drug development and clinical trials for patients with primary brain cancer 

  • Advancement of clinical trial methodology

  • Lead of the COGNO-led PICCOG study which will evaluate a novel treatment for patients with relapsed IDH-mutant gliomas